SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation

Polyp segmentation in colonoscopy images is crucial for detecting colorectal cancer but is challenging due to variations in the structure color and size of polyps as well as the lack of clear boundaries with surrounding tissues. Traditional segmentation models based on Convolutional Neural Networks (CNNs) struggle to capture detailed patterns and global context limiting their performance. Vision Transformer (ViT)-based models address some of these issues but have difficulties in capturing local context and lack strong zero-shot generalization. To this end we propose the Mamba-guided Segment Anything Model (SAM-Mamba) for efficient polyp segmentation. Our approach introduces a Mamba-Prior module in the encoder to bridge the gap between the general pre-trained representation of SAM and polyp-relevant trivial clues. It injects salient cues of polyp images into the SAM image encoder as a domain prior while capturing global dependencies at various scales leading to more accurate segmentation results. Extensive experiments on five benchmark datasets show that SAM-Mamba outperforms traditional CNN ViT and Adapter-based models in both quantitative and qualitative measures. Additionally SAM-Mamba demonstrates excellent adaptability to unseen datasets making it highly suitable for real-time clinical use.