CA-MLIF: Cross-Attention and Multimodal Low-Rank Interaction Fusion Framework for Tumor Prognostic Prediction

Abstract Cancer is a leading cause of death worldwide due to its aggressive nature and complex variability. Accurate prognosis is therefore challenging but essential for guiding personalized treatment and follow-up. Previous research often relied on single data sources, missing the opportunity to combine various types of patient information for more comprehensive survival predictions. To address these challenges, we propose a two-stage fusion method named Cross-Attention and Multimodal Low-Rank Interaction Fusion Framework (CA-MLIF). In the first stage, we propose a CA mechanism for real-time feature updates and cross-modal mutual learning to capture rich semantic information. In the second stage, we design a novel multimodal low-rank interaction fusion method for survival prediction. Specifically, we present modal attention mechanism (MAM) for feature filtration, low-rank multimodal fusion (LMF) for model complexity reduction, and optimal weight concatenation (OWC) for maximizing feature integration. Extensive experiments on two public datasets TCGA-GBMLGG and TCGA-KIRC, as well as a multi-center in-house lung adenocarcinoma (LUAD) dataset validate the effectiveness of CA-MLIF, which demonstrate that our method outperforms existing approaches in survival prediction under both pathology-gene fusion and CT-pathology fusion scenarios.