Toward Trustworthy AI for Decision Making in Population Health

Abstract AI and population health are becoming increasingly intertwined, driven by the growing availability of multimodal data and rapid advances in AI. At the AAAI-26 New Faculty Highlights, I present our efforts to harness these trends to enhance our capacity to model, simulate, and adapt to complex dynamical processes. I first introduce our robust deep learning architectures for real-time outbreak response, highlighting how our frameworks capture uncertainty and dynamics across shifting distributions, multimodal data, hierarchical structures, and relational dependencies. I will then introduce our hybrid approaches that integrate machine learning with science-based mechanistic epidemiological models, including physics-informed neural networks, expert-guided generative models for causal inference, and differentiable agent-based models. Together, these advances illustrate how combining data-driven AI with domain knowledge can enable more reliable, adaptive, and actionable solutions to inform decision making in population health.